A partial agonist of α2A-

TDIQ (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
15052-05-8
Storage:
-20
UN-No:
Non-Hazardous - /

TDIQ (hydrochloride) is an analytical reference standard that is classified as a phenylalkylamine. It is related in structure to amphetamines but does not appear to affect locomotor activity.{30507} TDIQ is a partial agonist of α2A-, α2B-, and α2C-adrenergic receptors (Kis = 75, 95, and 65 nM, respectively) but has low affinity for dopamine or serotonin receptors and does not affect catecholamine release in rodent brain synaptosomes.{30507} Drug discrimination studies in rats indicate that it can serve as a discriminative stimulus, generalizing to cocaine (Item Nos. 16186, ISO60176) and partially to 3,4-MDMA (Item Nos. 13971, ISO60190) and methcathinone (Item No. 11709), but not to amphetamine (Item Nos. 15797, 15650).{30507} TDIQ has also been shown to exhibit anxiolytic and anorectic effects in rodent models.{30507} This product is intended for forensic and research purposes.  

 

Add to quotes
SKU: - Category:

Description

A partial agonist of α2A-, α2B-, and α2C-adrenergic receptors (Kis = 75, 95, and 65 nM, respectively) that exhibits anxiolytic and anorectic effects in rodent models; acts as a discriminative stimulus, generalizing to cocaine in rat drug discrimination studies

Formal name: 5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline, monohydrochloride

Synonyms:  6,7-Methylenedioxy-1,2,3,4-tetrahydroisoquinoline|MDTHIQ

Molecular weight: 213.7

CAS: 15052-05-8

Purity: ≥95%

Formulation: A crystalline solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Drugs of Abuse||Research Area|Forensic Chemistry & Toxicology|Hallucinogens|Phenethylamines||Research Area|Forensic Chemistry & Toxicology|Stimulants|Phenethylamines

Related products

  • A small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state; activity is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM

    SC-1 – 10 mg

    The maintenance of embryonic stem cells in culture typically requires feeder cells and various exogenous factors found in serum. Murine embryonic stem (mES) cells can be maintained in the absence of feeder cells and serum but require the leukemia inhibitor factor (LIF) and bone morphogenic protein (BMP) to prevent differentiation and promote self-renewal. SC-1 is a small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state.{14533} The activity of SC-1 is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively.{14533} Inhibition of RasGAP increases Ras signaling via the PI3-kinase pathway which promotes self-renewal, whereas inhibition of ERK blocks differentiation.  

     

    Brand:
    Cayman
    SKU:10009557 - 10 mg

    Available on backorder

    Add to quotes
    View product page
  • A potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM; also inhibits Cdk7/cyclin H

    (R)-Roscovitine – 10 mg

    Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}  

     

    Brand:
    Cayman
    SKU:10009569 - 10 mg

    Available on backorder

    Add to quotes
    View product page
  • A zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers

    1,2-Dipalmitoyl-sn-glycero-3-PC – 25 mg

    1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}  

     

    Brand:
    Cayman
    SKU:10009473 - 25 mg

    Available on backorder

    Add to quotes
    View product page
  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 50 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 50 µg

    Available on backorder

    Add to quotes
    View product page