An HDAC6 inhibitor; inhibits the growth of HCT116 cells when used at a concentration of 5 µM in combination with paclitaxel but not when used alone; inhibits the growth of α-positive MCF-7 breast cancer cells treated with estrogen

TCS HDAC6 20b – 5 mg

Brand:
Cayman
CAS:
956154-63-5
Storage:
-20
UN-No:
De Minimis - 1170 / 3

TCS HDAC6 20b is an inhibitor of histone deacetylase 6 (HDAC6) that inhibits the growth of HCT116 cells synergistically when used at a concentration of 5 µM in combination with paclitaxel (Item No. 10461), but it has no activity on cell growth in HCT116 cells when used alone.{38310} It inhibits cell growth of α-positive MCF-7 breast cancer cells treated with estrogen but not untreated cells.  

 

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Description

An HDAC6 inhibitor; inhibits the growth of HCT116 cells when used at a concentration of 5 µM in combination with paclitaxel but not when used alone; inhibits the growth of α-positive MCF-7 breast cancer cells treated with estrogen,

Formal name: 2-methyl-propanethioic acid, S-[(6S)-6-[[(1,1-dimethylethoxy)carbonyl]amino]-7-oxo-7-(tricyclo[3.3.1.13,7]dec-1-ylamino)heptyl] ester

Synonyms: 

Molecular weight: 480.7

CAS: 956154-63-5

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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