A selective inhibitor of ERK2 (Ki 50 = 48 nM)

TCS ERK 11e – 1 mg

Brand:
Cayman
CAS:
896720-20-0
Storage:
-20
UN-No:
Non-Hazardous - /

TCS ERK 11e is an orally bioavailable inhibitor of extracellular signal-related kinase 2 (ERK2; Ki i values of 395, 540, and 852 nM, respectively.{32042} TCS ERK 11e has been shown to block the proliferation of HT29 cells with an IC50 value of 48 nM.{32042}  

 

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SKU: 19932 - Category:

Description

A selective inhibitor of ERK2 (Ki 50 = 48 nM)

Formal name: 4-[2-[(2-chloro-4-fluorophenyl)amino]-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide

Synonyms:  TCS Extracellular Signal-Related Kinase 11e|VX-11e

Molecular weight: 500.4

CAS: 896720-20-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|RAS/RAF/MEK/ERK/MAPK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling

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