A small molecule inducer of neuronal differentiation; increases expression of the neuronal markers β-III tubulin and NSE and induces neurite outgrowth in a population of PC12 neuronal precursor-like cells; converts >95% of a rat MSC population to a neuronal phenotype that exhibits potassium outward currents and increased expression of β-III tubulin and NSE as well as the cholinergic genes CHRNA2

TCS 2210 – 500 µg

Brand:
Cayman
CAS:
1201916-31-5
Storage:
-20
UN-No:
Non-Hazardous - /

TCS 2210 is a small molecule inducer of neuronal differentiation.{39439} It increases expression of the neuronal markers β-III tubulin and neuron-specific enolase (NSE) and induces neurite outgrowth in a population of PC12 neuronal precursor-like cells. TCS 2210 (20 μM per day for two days) converts >95% of a rat mesenchymal stem cell (MSC) population to a neuronal phenotype that exhibits potassium outward currents and increased expression of β-III tubulin and NSE as well as the cholinergic genes CHRNA2, CHRNAB, and CHRM4.  

 

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Description

A small molecule inducer of neuronal differentiation; increases expression of the neuronal markers β-III tubulin and NSE and induces neurite outgrowth in a population of PC12 neuronal precursor-like cells; converts >95% of a rat MSC population to a neuronal phenotype that exhibits potassium outward currents and increased expression of β-III tubulin and NSE as well as the cholinergic genes CHRNA2, CHRNAB, and CHRM4,

Formal name: 1,2-dihydro-N-hydroxy-2-oxo-3-(3-phenylpropyl)-6-quinoxalinecarboxamide

Synonyms: 

Molecular weight: 323.3

CAS: 1201916-31-5

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals||Research Area|Cell Biology|Stem Cell Research|Differentiation||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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