An agonist of GPR139 (EC50 = 39 nM in a calcium mobilization assay); selective for GPR139 over a panel of 90 additional targets; inhibits cell death induced by MPP+

TC-O 9311 – 10 mg

Brand:
Cayman
CAS:
444932-31-4
Storage:
-20
UN-No:
Non-Hazardous - /

TC-O 9311 is an agonist of the orphan G protein-coupled receptor GPR139 (EC50 = 39 nM in a calcium mobilization assay).{42984} It is selective for GPR139 over a panel of 90 additional targets. TC-O 9311 (1 μM) inhibits cell death induced by 1-methyl-4-phenylpyridinium (MPP+), but not 6-hydroxydopamine (6-OHDA; Item No. 25330), in primary dopaminergic midbrain neurons.{42985}  

 

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Description

An agonist of GPR139 (EC50 = 39 nM in a calcium mobilization assay); selective for GPR139 over a panel of 90 additional targets; inhibits cell death induced by MPP+, but not 6-OHDA, in primary dopaminergic midbrain neurons at 1 μM

Formal name: 3,5-dimethoxy-benzoic acid, 2-[(1-naphthalenylamino)carbonyl]hydrazide

Synonyms: 

Molecular weight: 365.4

CAS: 444932-31-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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