An agonist of FPR1 and FPR2; induces calcium flux in CHO cells expressing human FPR2

TC-FPR 43 – 5 mg

Brand:
Cayman
CAS:
903895-98-7
Storage:
-20
UN-No:
Non-Hazardous - /

TC-FPR 43 is an agonist of formyl peptide receptor 1 (FPR1) and FPR2, which was previously known as formyl peptide receptor-like 1 (FPRL1).{52690,52691} TC-FPR 43 induces calcium flux in CHO cells expressing human FPR2, Gα15, and aequorin (EC50 = 0.044 µM) and in CHO-K1 cells expressing either human FPR1, human FPR2, mouse Fpr1, or mouse Fpr2, Gα16, and aequorin in a concentration-dependent manner.{52691} TC-FPR 43 inhibits migration of polymorphonuclear (PMN) neutrophils induced by fMLP (Item No. 21495) or IL-8 with IC50 values of 0.64 and 0.24 µM, respectively.{52690} It also reduces ear swelling induced by prostaglandin E2 (PGE2; Item No. 14010) and leukotriene B4 (LTB4; Item No. 20110) in mice when administered at a dose of 50 mg/kg.  

 

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Description

An agonist of FPR1 and FPR2; induces calcium flux in CHO cells expressing human FPR2, Gα15, and aequorin (EC50 = 0.044 µM) and in CHO-K1 cells expressing either human FPR1, human FPR2, mouse Fpr1, or mouse Fpr2, Gα16, and aequorin in a concentration-dependent manner; inhibits fMLP- or IL-8-induced neutrophil migration (IC50s = 0.64 and 0.24 µM, respectively); reduces PGE2- and LTB4-induced ear swelling in mice at 50 mg/kg

Formal name: N-(4-chlorophenyl)-N′-[2,3-dihydro-1-methyl-5-(1-methylethyl)-3-oxo-2-phenyl-1H-pyrazol-4-yl]-urea

Synonyms:  FPR Agonist 43

Molecular weight: 384.9

CAS: 903895-98-7

Purity: ≥98%

Formulation: A crystalline solid

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