An allosteric agonist of M1 mAChRs (EC50 = 158 nM in CHO-K1 cells expressing rat recombinant receptors); selective for M1 over M2-5 receptors at concentrations up to 10 μM; potentiates NMDA-evoked currents in CA1 pyramidal cells at 3 μM; increases production of the non-amyloidogenic APP cleavage products APPsα and CTFα in PC12 cells overexpressing the human M1 receptor and APP at 1 μM; decreases amphetamine-induced hyperlocomotion in in a rat model that is predictive of antipsychotic-like activity

TBPB – 5 mg

Brand:
Cayman
CAS:
634616-95-8
Storage:
-20
UN-No:
Non-Hazardous - /

TBPB is an allosteric agonist of M1 muscarinic acetylcholine receptors (mAChRs; EC50 = 158 nM in CHO-K1 cells expressing rat recombinant receptors).{45505} It is selective for M1 over M2-5 receptors at concentrations up to 10 μM. TBPB (3 μM) potentiates NMDA-evoked currents in CA1 pyramidal cells. It increases production of the non-amyloidogenic amyloid precursor protein (APP) cleavage products APPsα and CTFα in PC12 cells overexpressing the human M1 receptor and APP when used at a concentration of 1 μM. TBPB decreases amphetamine-induced hyperlocomotion in a rat model that is predictive of antipsychotic-like activity.  

 

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SKU: 22943 - 5 mg Category:

Description

An allosteric agonist of M1 mAChRs (EC50 = 158 nM in CHO-K1 cells expressing rat recombinant receptors); selective for M1 over M2-5 receptors at concentrations up to 10 μM; potentiates NMDA-evoked currents in CA1 pyramidal cells at 3 μM; increases production of the non-amyloidogenic APP cleavage products APPsα and CTFα in PC12 cells overexpressing the human M1 receptor and APP at 1 μM; decreases amphetamine-induced hyperlocomotion in in a rat model that is predictive of antipsychotic-like activity

Formal name: 1,3-dihydro-1-[1′-[(2-methylphenyl)methyl][1,4′-bipiperidin]-4-yl]-2H-benzimidazol-2-one

Synonyms: 

Molecular weight: 404.6

CAS: 634616-95-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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