A selective

TBCA – 5 mg

Brand:
Cayman
CAS:
934358-00-6
Storage:
-20
UN-No:
Non-Hazardous - /

Casein kinase 2 (CK2) is a kinase with many targets and diverse roles in cell signaling and disease.{26170,26171} TBCA is a selective, cell-permeable inhibitor of CK2 (IC50 = 0.11 µM, Ki = 77 nM) that has minimal effect on a panel of 28 other kinases.{24973} It induces cell death in Jurkat adult T cell leukemia cells (DC50 = 7.7 µM), driving caspase-dependent degradation of poly-ADP ribose polymerase while inhibiting CK2 activity.{24973} TBCA also supports a role for CK2 in platelet function and Akt phosphorylation but not protein splicing.{26172,26173}  

 

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Description

A selective, cell-permeable inhibitor of CK2 (IC50 = 0.11 µM, Ki = 77 nM) that has minimal effect on a panel of 28 other kinases; induces cell death in Jurkat adult T cell leukemia cells (DC50 = 7.7 µM), driving caspase-dependent degradation of poly-ADP ribose polymerase while inhibiting CK2 activity

Formal name: (2E)-3-(2,3,4,5-tetrabromophenyl)-2-propenoic acid

Synonyms:  Casein Kinase II Inhibitor III|Tetrabromocinnamic Acid

Molecular weight: 463.7

CAS: 934358-00-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CK2||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Casein Kinase Signaling

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