A taurine-conjugated form of lithocholic acid; increases caspase-3 and -7 activity in NTCP-transfected Hep3B cells at 75 µM; has been used to induce cholestasis in ex vivo and in vivo animal models of hepatocellular cholestasis; serum levels of TLCA increase approximately 5-fold in within two hours during an oral lipid tolerance test in humans

Taurolithocholic Acid (sodium salt) – 5 mg

Brand:
Cayman
CAS:
6042-32-6
Storage:
-20
UN-No:
Non-Hazardous - /

Taurolithocholic acid (TLCA) is a taurine-conjugated form of the secondary bile acid lithocholic acid (Item No. 20253).{33902} TLCA (75 μM) increases caspase-3 and -7 activity in Hep3B cells transfected with sodium taurocholate cotransporting peptide (NTCP), but not nontransfected Hep3B cells.{28235} It has been used to induce cholestasis in ex vivo and in vivo animal models of hepatocellular cholestasis.{28234,43818} Serum levels of TLCA increase approximately 5-fold in within two hours during an oral lipid tolerance test in humans.{33902}  

 

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Description

A taurine-conjugated form of lithocholic acid; increases caspase-3 and -7 activity in NTCP-transfected Hep3B cells at 75 µM; has been used to induce cholestasis in ex vivo and in vivo animal models of hepatocellular cholestasis; serum levels of TLCA increase approximately 5-fold in within two hours during an oral lipid tolerance test in humans

Formal name: 2-[[(3α,5β)-3-hydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid, monosodium salt

Synonyms:  NSC 681057|Sodium taurolithocholate|TLCA

Molecular weight: 505.7

CAS: 6042-32-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Endocrinology & Metabolism|Bile Acids & Microbiome

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