Taurolithocholic Acid-d5 (sodium salt) – 1 mg

Brand:
Cayman
CAS:
1265476-97-8
Storage:
-20
UN-No:
Non-Hazardous - /

Taurolithocholic acid-d5 (TLCA-d5) is intended for use as an internal standard for the quantification of TLCA (Item No. 17275) by GC- or LC-MS. TLCA is a taurine-conjugated form of the secondary bile acid lithocholic acid (Item No. 20253).{33902} TLCA (75 μM) increases caspase-3 and -7 activity in Hep3B cells transfected with sodium taurocholate cotransporting peptide (NTCP), but not nontransfected Hep3B cells.{28235} It has been used to induce cholestasis in ex vivo and in vivo animal models of hepatocellular cholestasis.{28234,43818} Serum levels of TLCA increase approximately 5-fold within two hours during an oral lipid tolerance test in humans.{33902}  

 

Available on backorder

SKU: 31312 - 1 mg Category:

Description

An internal standard for the quantification of taurolithocholic acid by GC- or LC-MS


Formal name: 2-[[(3α,5β)-3-hydroxy-24-oxocholan-24-yl-2,2,3,4,4-d5]amino]-ethanesulfonic acid, monosodium salt

Synonyms:  Taurolithocholate-d5|TLCA-d5

Molecular weight: 510.7

CAS: 1265476-97-8

Purity: ≥99% deuterated forms (d1-d5)

Formulation: A solid