A melatonin receptor agonist (Kis = 0.304 and 0.069 nM for MT1 and MT2

Tasimelteon – 5 mg

Brand:
Cayman
CAS:
609799-22-6
Storage:
-20
UN-No:
Non-Hazardous - /

Tasimelteon is a melatonin (MT) receptor agonist (Kis = 0.304 and 0.069 nM for MT1 and MT2, respectively, in NIH3T3 cells).{38574} It is selective for MT receptors over 160 other receptors and enzymes. Tasimelteon increases cAMP accumulation induced by forskolin (Item No. 11018) with EC50 values of 0.79 and 1 nM for NIH3T3 cells expressing MT1 and MT2, respectively. Formulations containing tasimelteon have been used in the treatment of non-24-hour sleep-wake disorder.  

 

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SKU: 23546 - 5 mg Category:

Description

A melatonin receptor agonist (Kis = 0.304 and 0.069 nM for MT1 and MT2, respectively, in NIH3T3 cells); selective for MT receptors over 160 other receptors and enzymes; increases cAMP accumulation induced by forskolin with EC50 values of 0.79 and 1 nM for NIH3T3 cells expressing MT1 and MT2, respectively

Formal name: N-[[(1R,2R)-2-(2,3-dihydro-4-benzofuranyl)cyclopropyl]methyl]-propanamide

Synonyms:  BMS 214778

Molecular weight: 245.3

CAS: 609799-22-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Behavioral Neuroscience|Sleep & Biological Rhythms

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