An orally bioavailable inhibitor of FGFRs that irreversibly inhibits all four FGFR subtypes at nanomolar concentrations; blocks the proliferation of human cancer cell lines with FGFR gene abnormalities

TAS 120 – 5 mg

Brand:
Cayman
CAS:
1448169-71-8
Storage:
-20
UN-No:
Non-Hazardous - /

TAS 120 is an orally bioavailable inhibitor of fibroblast growth factor receptors (FGFRs) that irreversibly inhibits all four FGFR subtypes at nanomolar concentrations.{34144} It prevents phosphorylation of FGFRs and impedes downstream signaling pathways in cells.{34144} TAS 120 blocks the proliferation of human cancer cell lines with FGFR gene abnormalities but does not alter the growth of cell lines with wild-type FGFR.{34144} It inhibits FGFR phosphorylation in tumors and tumor growth in human xenograft mouse models in a dose-dependent manner.{34144}  

 

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Description

An orally bioavailable inhibitor of FGFRs that irreversibly inhibits all four FGFR subtypes at nanomolar concentrations; blocks the proliferation of human cancer cell lines with FGFR gene abnormalities

Formal name: 1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-pyrrolidinyl]-2-propen-1-one

Synonyms: 

Molecular weight: 418.5

CAS: 1448169-71-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|FGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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