A tanshinone IIA derivative with immunomodulatory activity; reduces CSE-induced secretion of IL-6 and IL-8 and prevents CSE-induced decreases in CFTR levels in 16HBE cells; reduces lung function decline

Tanshinone IIA sulfonate (sodium salt) – 10 mg

Brand:
Cayman
CAS:
69659-80-9
Storage:
-20
UN-No:
Non-Hazardous - /

Tanshinone IIA sulfonate is a derivative of tanshinone IIA (Item No. 14323) and has immunomodulatory activities.{52201,52202} It reduces secretion of IL-6 and IL-8 induced by cigarette smoke extract (CSE) and prevents CSE-induced decreases in cystic fibrosis transmembrane conductance regulator (CFTR) levels in 16HBE human bronchial epithelial cells.{52201} Inhalation of tanshinone IIA sulfonate (5 mg/kg) reduces lung function decline, mucus production, bronchial collagen deposition, and airspace enlargement in a mouse model of CS-induced chronic obstructive pulmonary disease (COPD). Tanshinone IIA sulfonate (15 mg/kg) reduces myocardial necrosis and production of TNF-α and IL-6 in a mouse model of sepsis induced by cecal ligation and puncture (CLP).{52202} It reduces the number of peripheral CD4+ and CD8+ T cells and prolongs allogeneic skin graft survival in a rat transplantation model.{52203}  

 

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SKU: 29229 - 10 mg Category:

Description

A tanshinone IIA derivative with immunomodulatory activity; reduces CSE-induced secretion of IL-6 and IL-8 and prevents CSE-induced decreases in CFTR levels in 16HBE cells; reduces lung function decline, mucus production, bronchial collagen deposition, and airspace enlargement in a mouse model of CS-induced COPD at 5 mg/kg; reduces myocardial necrosis and production of TNF-α and IL-6 in a mouse model of CLP-induced sepsis at 15 mg/kg; reduces the number of peripheral CD4+ and CD8+ T cells and prolongs allogeneic skin graft survival in a rat transplantation model.

Formal name: 6,7,8,9,10,11-hexahydro-1,6,6-trimethyl-10,11-dioxo-phenanthro[1,2-b]furan-2-sulfonic acid, monosodium salt

Synonyms:  Sodium Tanshinone IIA sulfonate|Sulfotanshinone sodium II-A

Molecular weight: 396.4

CAS: 69659-80-9

Purity: ≥98%

Formulation: A crystalline solid

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