A natural product with anti-inflammatory and cytotoxic activity; inhibits production of TNFα

Tanshinone IIA – 5 mg

Brand:
Cayman
CAS:
568-72-9
Storage:
-20
UN-No:
Non-Hazardous - /

Tanshinone IIA (TSA) is a major lipophilic component of extracts from the root of S. miltiorrhiza, used widely in Chinese herbal medicine. It has anti-inflammatory activity, inhibiting production of TNF-α, IL-1β, IL-6, NO, INFγ, and expression of iNOS, and IL-12.{23549,23547} It blocks human aortic smooth muscle cell migration, inhibits MMP-9 activity, and interferes with PI3K/Akt and ERK1/2 signaling pathways.{23548} It is cytotoxic to various cancer cells including A549 lung cancer cells and leukemia cells.{23545,23544}Reduction of TSA by NAD(P)H:quinone oxidoreductase (NQO1) generates an unstable intermediate resulting in reactive oxygenase species-mediated apoptotic cell death.{23546}  

 

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Description

A natural product with anti-inflammatory and cytotoxic activity; inhibits production of TNFα, IL-1β, IL-6, NO, INFγ, and expression of iNOS, and IL-12; blocks human aortic smooth muscle cell migration, inhibits MMP-9 activity, and interferes with PI3K/Akt and ERK1/2 signaling pathways

Formal name: 6,7,8,9-tetrahydro-1,6,6-trimethyl-phenanthro[1,2-b]furan-10,11-dione

Synonyms:  NSC 686518|NSC 686519|TSA

Molecular weight: 294.3

CAS: 568-72-9

Purity: ≥97%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cancer|Cell Death||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling||Research Area|Cancer|Cell Signaling|Nitric Oxide Signaling||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cardiovascular System|Vasculature|Endothelium||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Signaling|ERK/MAPK Signaling||Research Area|Cell Biology|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Immunology & Inflammation

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