A polymethoxylated flavone isolated from citrus peels; inhibits signaling in cancer cells

Tangeritin – 1 mg

Brand:
Cayman
CAS:
481-53-8
Storage:
-20
UN-No:
Excepted Quantity - 2811 / 6.1

Tangeritin is a polymethoxylated flavone isolated from peels of citrus fruits. It inhibits signaling in cancer cells, reducing ERK phosphorylation and growth of estradiol-stimulated T47D breast cancer cells (IC50 ~ 3 μM){16516} and blocking p38 MAPK, JNK, and Akt activation in interleukin-1β-stimulated human lung carcinoma A549 cells.{16517} Tangeritin activates the pregnane X receptor, inducing MDR1 expression in human colonic LS180 cancer cells at a concentration of 10 μM.{16518} It also inhibits growth of tumors and tumor implantation in lungs of mice inoculated with murine melanoma B16F10 cells.{16519} Tangeritin has been shown to protect against tunicamycin-induced cell death in isolated murine insulinoma MIN6 cells and in renal tubular epithelium in mice at a concentration of 10 μM.{16520} More recently, tangeritin has been found to significantly reduce serum total and LDL cholesterol and triacylglycerols in hypercholesteremic hamsters.{16521}  

 

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SKU: 10009911 - 1 mg Category:

Description

A polymethoxylated flavone isolated from citrus peels; inhibits signaling in cancer cells, reducing ERK signaling in T47D breast cancer cells (IC50 ~3 μM)

Formal name: 5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one

Synonyms:  NSC 53909|NSC 618905|Ponkanetin

Molecular weight: 372.4

CAS: 481-53-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Flavonoids||Research Area|Cancer|Cell Signaling|JNK Signaling||Research Area|Cancer|Cell Signaling|p38 MAPK Signaling||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cancer|Multidrug Resistance||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins

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