A bacterial metabolite; scavenges DPPH radicals in vitro (IC50 = 1.3 μM); reduces TBARS in rat liver microsomes by 72% at 100 μg/ml; is active against B. brevis

TAN 420E – 500 µg

Brand:
Cayman
CAS:
91700-93-5
Storage:
-20
UN-No:
Non-Hazardous - /

TAN 420E is a bacterial metabolite originally isolated from Streptomyces.{38266,38265,47368} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 1.3 μM) and reduces thiobarbituric acid reactive substances (TBARS) in rat liver microsomes by 72% when used at a concentration of 100 μg/ml.{47368} TAN 420E is active against B. brevis, B. cereus, M. flavus, and S. aureus (MICs = 50-100 μg/ml).{38266} It is cytotoxic to P388 and KB lymphocytic leukemia cells (EC50s = 0.022 and 0.3 μg/ml, respectively).{38265}  

 

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SKU: 28120 - 500 µg Category:

Description

A bacterial metabolite; scavenges DPPH radicals in vitro (IC50 = 1.3 μM); reduces TBARS in rat liver microsomes by 72% at 100 μg/ml; is active against B. brevis, B. cereus, M. flavus, and S. aureus (MICs = 50-100 μg/ml); is cytotoxic to P388 and KB lymphocytic leukemia cells (EC50s = 0.022 and 0.3 μg/ml, respectively)

Formal name: (15R)-18,21-didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-15-methoxy-11-O-methyl-geldanamycin

Synonyms:  Dihydroherbimycin A

Molecular weight: 576.7

CAS: 91700-93-5

Purity: ≥95%

Formulation: A lyophilisate

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