A metabolite of tamoxifen that is produced by the action of flavin-containing monooxygenases

Tamoxifen N-oxide – 10 mg

Brand:
Cayman
CAS:
75504-34-6
Storage:
-20
UN-No:
Non-Hazardous - /

Tamoxifen (Item No. 13258) is a selective estrogen receptor modulator that evokes tissue-dependent effects.{17813,17814,17815,17816} Tamoxifen N-oxide is a metabolite of tamoxifen that is produced by the action of flavin-containing monooxygenases.{30184,30180} It can be converted back to tamoxifen by cytochrome P450 isoforms and hemoglobin.{30179,30180} Like the parent compound, tamoxifen N-oxide can form DNA adducts.{30181,30182,30184} Tamoxifen N-oxide is a weak inhibitor of human hydroxysteroid sulfotransferase 2A1 (Kis = 9.1 and 16.9 µM for the sulfonation of dehydroepiandrosterone and pregnenolone, respectively).{30183}  

 

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Description

A metabolite of tamoxifen that is produced by the action of flavin-containing monooxygenases

Formal name: N-oxide-2-[4-[(1Z)-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethyl, ethanamine

Synonyms: 

Molecular weight: 387.5

CAS: 75504-34-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cancer|DNA Damage and Repair||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins

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