A diterpene alkaloid with diverse biological activities; blocks IK current in rat hippocampal neurons (IC50 = 146 μM); reduces Aβ40-induced increases in IK current and cytotoxicity in primary rat cortical neurons; inhibits barium chloride-induced contractions in isolated rat intenstines (EC50 = 200 μM); exhibits feeding deterrent activity against red flour beetle (T. castaneum) adults (EC50 = 342.8 ppm)

Talatisamine – 10 mg

Brand:
Cayman
CAS:
20501-56-8
Storage:
-20
UN-No:
Non-Hazardous - /

Talatisamine is a diterpene alkaloid originally isolated from A. talassicum and has diverse biological activities.{47536,47537,47538,47539,47540} It blocks delayed rectifier potassium (IK) current in rat hippocampal neurons (IC50 = 146 μM).{47538} Talatisamine reduces increases in IK current and cytotoxicity in primary rat cortical neurons induced by amyloid-β (1-40) (Aβ40; Item No. 21617).{47539} It inhibits barium chloride-induced contractions in isolated rat intenstines (EC50 = 200 μM).{47537} Talatisamine exhibits feeding deterrent activity against red flour beetle (T. castaneum) adults (EC50 = 342.8 ppm).{47540}  

 

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SKU: 27721 - 10 mg Category:

Description

A diterpene alkaloid with diverse biological activities; blocks IK current in rat hippocampal neurons (IC50 = 146 μM); reduces Aβ40-induced increases in IK current and cytotoxicity in primary rat cortical neurons; inhibits barium chloride-induced contractions in isolated rat intenstines (EC50 = 200 μM); exhibits feeding deterrent activity against red flour beetle (T. castaneum) adults (EC50 = 342.8 ppm)

Formal name: 20-ethyl-1α,16β-dimethoxy-4-(methoxymethyl)-aconitane-8,14α-diol

Synonyms: 

Molecular weight: 421.6

CAS: 20501-56-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation||Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Natural Products|Terpenes||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Toxicology|Environmental

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