An allosteric AMPA receptor antagonist (IC50 = 2.5 µM); reduces the firing rate of spinal neurons in rats by 68% at 10 mg/kg following AMPA administration; protective in mouse models of MES-induced (ED50 = 8.6 mg/kg) and 4-aminopyridine-induced seizures (ED50 = 8.4 mg/kg); potentiates the effects of diazepam in MES- and metrazole-induced seizure models at 2 mg/kg; reduces lesion size in rat and mouse models of focal ischemia

Talampanel – 5 mg

Brand:
Cayman
CAS:
161832-65-1
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Talampanel is an allosteric AMPA receptor antagonist (IC50 = 2.5 µM in cerebellar Purkinje neurons using voltage-clamp electrophysiology).{39888} It reduces the firing rate of spinal neurons in rats by 68% when administered at a dose of 10 mg/kg following AMPA administration.{39889} It is protective against seizures in mouse models of epilepsy including maximum electroshock (MES; ED50 = 8.6 mg/kg) and 4-aminopyridine models (Item No. 18511; ED50 = 8.4 mg/kg). It also potentiates the effects of diazepam in MES- and metrazole-induced seizure models when administered at a dose of 2 mg/kg.{39890} Talampanel is neuroprotective, reducing lesion size in rat and mouse models of focal ischemia.  

 

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Description

An allosteric AMPA receptor antagonist (IC50 = 2.5 µM); reduces the firing rate of spinal neurons in rats by 68% at 10 mg/kg following AMPA administration; protective in mouse models of MES-induced (ED50 = 8.6 mg/kg) and 4-aminopyridine-induced seizures (ED50 = 8.4 mg/kg); potentiates the effects of diazepam in MES- and metrazole-induced seizure models at 2 mg/kg; reduces lesion size in rat and mouse models of focal ischemia

Formal name: (8R)-7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine

Synonyms:  GYKI 53773|LY 300164

Molecular weight: 337.4

CAS: 161832-65-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience|Neuroprotection|Ischemia||Research Area|Neuroscience|Seizure Disorders

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