A PDE5 inhibitor (IC50 = 1.2 nM); selective for PDE5 over PDE1-4 and 7-10 (IC50s = 9.2-280 μM); also inhibits PDE11 (IC50 = 11 nM); decreases production of the proinflammatory cytokines TNF-α

Tadalafil – 10 mg

Brand:
Cayman
CAS:
171596-29-5
Storage:
-20
UN-No:
Non-Hazardous - /

Tadalafil is a potent inhibitor of phosphodiesterase 5 (PDE5; IC50 = 1.2 nM).{24530} It is selective for PDE5 over PDE1-4 and 7-10 (IC50s = 9.2-280 μM), however, it does also inhibit PDE11 (IC50 = 11 nM). In vivo, tadalafil (10 mg/kg) decreases production of the proinflammatory cytokines TNF-α, IL-1β, and IL-6 and improves renal function in a rat model of ischemia/reperfusion injury.{41848} It also reduces development of tobacco smoke-induced emphysema and pulmonary hypertension in mice.{41849} Formulations containing tadalafil have been used to treat erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction.  

 

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Description

A PDE5 inhibitor (IC50 = 1.2 nM); selective for PDE5 over PDE1-4 and 7-10 (IC50s = 9.2-280 μM); also inhibits PDE11 (IC50 = 11 nM); decreases production of the proinflammatory cytokines TNF-α, IL-1β, and IL-6 and improves renal function in a rat model of ischemia/reperfusion injury at 10 mg/kg; reduces development of tobacco smoke-induced emphysema and pulmonary hypertension in mice

Formal name: (6R)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12aR-hexahydro-2-methyl-pyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione

Synonyms: 

Molecular weight: 389.4

CAS: 171596-29-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Cell Biology|Cell Signaling|cAMP Signaling||Research Area|Cell Biology|Cell Signaling|cGMP Signaling

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