An inducer of cardiomyocyte differentiation; increases expression of the cardiomyocyte marker NKX2-5 by 2.2-fold and decreases expression of mesoderm markers and the pre-cardiac marker Isl-1 in HES-3 NKX2-5eGFP/w cells at

TA-01 – 10 mg

Brand:
Cayman
CAS:
1784751-18-3
Storage:
-20
UN-No:
Non-Hazardous - /

TA-01 is a derivative of the p38 MAPK inhibitor SB 203580 (Item Nos. 13067 | 13344) and an inducer of cardiomyocyte differentiation.{41744} It is cardiomyogenic at concentrations less than 5 μM, increasing expression of the cardiomyocyte marker NKX2-5 by 2.2-fold and decreasing expression of mesoderm markers and the pre-cardiac marker Isl-1 in HES-3 NKX2-5eGFP/w cells when applied after embryoid body formation. TA-01 inhibits casein kinase 1ε (CK1ε) and CK1Δ and reduces expression of Wnt/β-catenin signaling pathway members, activities that positively correlate with its cardiomyogenic activity.  

 

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SKU: 24667 - 10 mg Category:

Description

An inducer of cardiomyocyte differentiation; increases expression of the cardiomyocyte marker NKX2-5 by 2.2-fold and decreases expression of mesoderm markers and the pre-cardiac marker Isl-1 in HES-3 NKX2-5eGFP/w cells at <5 μM; inhibits CK1ε and CK1Δ and reduces expression of Wnt/β-catenin signaling pathway members

Formal name: 4-[2-(2,6-difluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]-pyridine

Synonyms: 

Molecular weight: 351.3

CAS: 1784751-18-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CK1||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Stem Cell Research|Differentiation

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