An inhibitor of Skp2; inhibits the interaction between Skp2 and Skp1 to block Skp2 E3 ubiquitin ligase activity at 5 μM; inhibits Skp2 over Fbw7 and β-TrCP E3 ubiquitin ligase activity in HEK293T cells; reduces survival of LNCaP and PC3 prostate cancer cells via inhibition of aerobic glycolysis and induction of apoptosis; reduces tumor volume in A549 lung cancer and PC3 prostate cancer mouse xenograft models at 40 and 80 mg/kg

SZL P1-41 – 50 mg

Brand:
Cayman
CAS:
222716-34-9
Storage:
-20
UN-No:
Non-Hazardous - /

SZL P1-41 is an inhibitor of the Skp1-Cullin1-F-box (SCF) family protein Skp2.{45204} It inhibits the interaction between Skp2 and Skp1 to block Skp2 E3 ubiquitin ligase activity when used at a concentration of 5 μM. SZL P1-41 selectively inhibits Skp2 over Fbw7 and β-TrCP E3 ubiquitin ligase activity in HEK293T cells. It reduces survival of LNCaP and PC3 prostate cancer cells in a concentration-dependent manner via inhibition of aerobic glycolysis and induction of apoptosis. SZL P1-41 (40 and 80 mg/kg) reduces tumor volume in A549 lung cancer and PC3 prostate cancer mouse xenograft models.  

 

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SKU: 26142 - 50 mg Category:

Description

An inhibitor of Skp2; inhibits the interaction between Skp2 and Skp1 to block Skp2 E3 ubiquitin ligase activity at 5 μM; inhibits Skp2 over Fbw7 and β-TrCP E3 ubiquitin ligase activity in HEK293T cells; reduces survival of LNCaP and PC3 prostate cancer cells via inhibition of aerobic glycolysis and induction of apoptosis; reduces tumor volume in A549 lung cancer and PC3 prostate cancer mouse xenograft models at 40 and 80 mg/kg

Formal name: 3-(2-benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one

Synonyms: 

Molecular weight: 420.5

CAS: 222716-34-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Ubiquitin Ligase System||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Metabolism

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