An oxindole compound that potently blocks Syk activity (IC50 = 14 nM) and inhibits FcεRI-mediated rat RBL-2H3 basophil cell degranulation (EC50 = 313 nM); 2 μM completely abolishes convulxin-induced platelet aggregation and shape change

Syk Inhibitor – 10 mg

Brand:
Cayman
CAS:
622387-85-3
Storage:
-20
UN-No:
Non-Hazardous - /

Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs (ITAMs) of FcRγ chains and mediates downstream signaling related to platelet function and inflammation.{24052} Syk inhibitor is an oxindole compound that potently blocks Syk activity with an IC50 value of 14 nM and inhibits FcεRI-mediated rat RBL-2H3 basophil cell degranulation (EC50 = 313 nM).{24050} At 2 μM, this compound completely abolishes convulxin-induced platelet aggregation and shape change.{24051}  

 

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Description

An oxindole compound that potently blocks Syk activity (IC50 = 14 nM) and inhibits FcεRI-mediated rat RBL-2H3 basophil cell degranulation (EC50 = 313 nM); 2 μM completely abolishes convulxin-induced platelet aggregation and shape change

Formal name: 2,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-1H-indole-5-sulfonamide

Synonyms:  OXSI 2|Spleen Tyrosine Kinase

Molecular weight: 353.4

CAS: 622387-85-3

Purity: ≥95% (mixture of isomers)

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Non-Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Immunology & Inflammation|Innate Immunity

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