A potent inhibitor of 15-PGDH (Ki = ~0.1 nM) that has activity in vivo; rapidly increases the levels of PGE2 in bone marrow and other tissues in mice after intraperitoneal injection

SW033291 – 10 mg

Brand:
Cayman
CAS:
459147-39-8
Storage:
-20
UN-No:
Non-Hazardous - /

The enzyme 15-hydroxy prostaglandin dehydrogenase (15-PGDH) initiates the catabolism of PGs and related eicosanoids.{20452,20456} SW033291 is a potent inhibitor of 15-PGDH (Ki = ~0.1 nM) that has activity in vivo.{29053} It rapidly increases the levels of PGE2 in bone marrow and other tissues in mice after intraperitoneal injection.{29053} SW033291 accelerates hematopoietic recovery in mice receiving bone marrow transplant and promotes tissue regeneration in mouse models of colon and liver injury.{29053}  

 

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Description

A potent inhibitor of 15-PGDH (Ki = ~0.1 nM) that has activity in vivo; rapidly increases the levels of PGE2 in bone marrow and other tissues in mice after intraperitoneal injection

Formal name: 2-(butylsulfinyl)-4-phenyl-6-(2-thienyl)-thieno[2,3-b]pyridine-3-amine

Synonyms: 

Molecular weight: 412.6

CAS: 459147-39-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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