An inhibitor of tubulin polymerization (IC50 = 0.38 μM) with anticancer activit; inhibits the proliferation of HeLa

Suprafenacine – 10 mg

Brand:
Cayman
CAS:
1477482-50-0
Storage:
-20
UN-No:
Non-Hazardous - /

Suprafenacine is an inhibitor of tubulin polymerization (IC50 = 0.38 μM) with anticancer activity.{54243} It inhibits the proliferation of HeLa, Jurkat, SNU-16, MDA-MB-231, A549, SH-SY5Y, HCT15, and KB-3-1 cells (IC50s = 83-381.2 nM) and P-glycoprotein-enriched KB-VI cells (IC50 = 215.7 nM). Suprafenacine (10 μM) increases phosphorylation of JNK and Bcl-2 and induces apoptosis and cell cycle arrest at the G2/M phase in HeLa cells. Suprafenacine (20 mg/kg) reduces tumor growth in an HCT15 colon adenocarcinoma mouse xenograft model.  

 

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SKU: 31158 - 10 mg Category:

Description

An inhibitor of tubulin polymerization (IC50 = 0.38 μM) with anticancer activit; inhibits the proliferation of HeLa, Jurkat, SNU-16, MDA-MB-231, A549, SH-SY5Y, HCT15, and KB-3-1 cells (IC50s = 83-381.2 nM) and P-glycoprotein-enriched KB-VI cells (IC50 = 215.7 nM); increases phosphorylation of JNK and Bcl-2 and induces apoptosis and cell cycle arrest at the G2/M phase in HeLa cells at 10 μM; reduces tumor growth in an HCT15 colon adenocarcinoma mouse xenograft model at 20 mg/kg

Formal name: 4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid (2E)-2-[(4-methylphenyl)methylene]hydrazide

Synonyms:  SML1493

Molecular weight: 282.3

CAS: 1477482-50-0

Purity: ≥98%

Formulation: A solid

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