An agonist of 5-HT1B and 5-HT1D receptors (IC50s = 9.3 and 7.3 nM

Sumatriptan (succinate) – 50 mg

Brand:
Cayman
CAS:
103628-48-4
Storage:
-20
UN-No:
Non-Hazardous - /

Sumatriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 9.3 and 7.3 nM, respectively).{23129} It also binds to the 5-HT1F receptor (IC50 = 17.8 nM). It induces vasoconstriction in isolated human middle meningeal arteries (EC50 = 89.9 nM), an effect that can be reduced by the 5-HT1B/1D receptor antagonists GR125,743 and GR127,935. Sumatriptan reduces acute, but not chronic, mechanical hyperalgesia in a mouse model of pain induced by nitroglycerin, which is a known migraine trigger in humans.{48340} Formulations containing sumatriptan have been used in the treatment of migraine headache.  

 

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Description

An agonist of 5-HT1B and 5-HT1D receptors (IC50s = 9.3 and 7.3 nM, respectively); binds to the 5-HT1F receptor (IC50 = 17.8 nM); induces vasoconstriction in isolated human middle meningeal arteries (EC50 = 89.9 nM); reduces acute, but not chronic, mechanical hyperalgesia in a mouse model of nitroglycerin-induced pain

Formal name: 3-[2-(dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide-butanedioic acid

Synonyms:  GR 43175C

Molecular weight: 413.5

CAS: 103628-48-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Cardiovascular Diseases||Research Area|Cardiovascular System|Vasculature|Vasoconstriction||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Pain Research

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