A fungal metabolite; active against a panel of 15 fungal strains (MICs = 0.8-50 μg/ml); cytotoxic to B16/F10

Sultriecin – 500 µg

Brand:
Cayman
CAS:
131774-59-9
Storage:
-20
UN-No:
Non-Hazardous - /

Sultriecin is a fungal metabolite originally isolated from S. roseiscleroticus.{46276} It is active against a panel of 15 fungal strains (MICs = 0.8-50 μg/ml). Sultriecin is cytotoxic to B16/F10, HCT116, Moser, P388, A549, and K562 cancer cells (IC50s = 37.7, 1.92, 0.85, 3.8, 4.14, and 0.67 μg/ml, respectively). It also inhibits RNA and protein synthesis in L1210 leukemia cells (IC50s = 5.5 and 2.4 μg/ml, respectively). Sultriecin (0.1-10 mg/kg) increases survival time in a B16/F10 syngeneic mouse melanoma model and a P388 murine leukemia model.  

 

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Description

A fungal metabolite; active against a panel of 15 fungal strains (MICs = 0.8-50 μg/ml); cytotoxic to B16/F10, HCT116, Moser, P388, A549, and K562 cancer cells (IC50s = 37.7, 1.92, 0.85, 3.8, 4.14, and 0.67 μg/ml, respectively); inhibits RNA and protein synthesis in L1210 leukemia cells (IC50s = 5.5 and 2.4 μg/ml, respectively); increases survival time in a B16/F10 syngeneic mouse melanoma model and a P388 murine leukemia model from 0.1-10 mg/kg

Formal name: (5S,6S)-5,6-dihydro-5-hydroxy-6-[(1E,4S,5S,6S,7Z,9Z,11E)-6-hydroxy-5-methyl-4-(phosphonooxy)-1,7,9,11-heptadecatetraen-1-yl]-2H-pyran-2-one, monosodium salt

Synonyms:  BU-3285T|Phostriecin

Molecular weight: 492.5

CAS: 131774-59-9

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer|Cell Death||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases

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