An oxidized metabolite of sulindac that is produced in many mammals but minimally in mice and rats; generally considered to be inactive against COX enzymes

Sulindac sulfone – 1 mg

Brand:
Cayman
CAS:
59864-04-9
Storage:
-20
UN-No:
Non-Hazardous - /

Sulindac (Item No. 10004386) is a non-steroidal anti-inflammatory drug that has an extensive epidemiology documenting reduced human colorectal cancer. In mouse models, sulindac was found not only to inhibit the enzymatic activity of polyp-associated COX-2, but also to downregulate the expression of colonic COX-2 protein to control levels.{4068} Sulindac sulfone is an oxidized metabolite of sulindac that is produced in many mammals but minimally in mice and rats.{27308,27307} It is generally considered to be inactive against COX enzymes, although it can reduce azoxymethane-induced colon cancer in rats.{12989,27310} Sulindac sulfone inhibits aldose reductase (IC50 = 367 nM) in vitro and may contribute to the beneficial pharmacological effects of sulindac on type 2 diabetic complications.{27311}  

 

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Description

An oxidized metabolite of sulindac that is produced in many mammals but minimally in mice and rats; generally considered to be inactive against COX enzymes, although it can reduce azoxymethane-induced colon cancer in rats; inhibits aldose reductase (IC50 = 367 nM) in vitro

Formal name: 5-fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-1H-indene-3-acetic acid

Synonyms:  Exisulind

Molecular weight: 372.4

CAS: 59864-04-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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