A sulfonamide antibiotic and nonpeptide ET receptor antagonist (IC50s = 0.6 and 22 μM for the ETA and ETB receptors

Sulfisoxazole – 10 g

Brand:
Cayman
CAS:
127-69-5
Storage:
-20
UN-No:
Non-Hazardous - /

Sulfisoxazole is a sulfonamide antibiotic and nonpeptide endothelin (ET) receptor antagonist (IC50s = 0.6 and 22 μM for the ETA and ETB receptors, respectively).{47039,47040} It inhibits the growth of Gram-positive and Gram-negative bacteria in vitro, including S. pneumoniae, B. subtilis, S. epidermidis, E. coli, and K. pneumoniae (MICs = 1.95, 0.98, 7.81, 62.5, and 7.81 μg/mL, respectively).{47041} Sulfisoxazole inhibits phosphoinositide turnover stimulated by endothelin-1 (ET-1; Item No. 24127) in TE671 cells. It inhibits ET-induced contraction of rat pulmonary artery rings ex vivo when used at concentrations of 0.1 and 1 mM.{47040} Sulfisoxazole (1,000 mg/kg per day) reduces atrial natriuretic peptide levels in myocytes and plasma and increases survival in a rat model of pulmonary hypertension induced by monocrotaline (MCT; Item No. 16666) as well as blocks MCT-induced increases in pulmonary artery blood pressure when administered at doses of 300 and 1,000 mg/kg.  

 

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Description

A sulfonamide antibiotic and nonpeptide ET receptor antagonist (IC50s = 0.6 and 22 μM for the ETA and ETB receptors, respectively); inhibits the growth of Gram-positive and Gram-negative bacteria in vitro, including S. pneumoniae, B. subtilis, S. epidermidis, E. coli, and K. pneumoniae (MICs = 1.95, 0.98, 7.81, 62.5, and 7.81 μg/mL, respectively); inhibits phosphoinositide turnover stimulated by ET-1 in TE671 cells; inhibits ET-induced contraction of rat pulmonary artery rings ex vivo at 0.1 and 1 mM; reduces atrial natriuretic peptide levels in myocytes and plasma and increases survival in a rat model of pulmonary hypertension induced by MCT at 1,000 mg/kg per day; blocks MCT-induced increases in pulmonary artery blood pressure at 300 and 1,000 mg/kg

Formal name: 4-amino-N-(3,4-dimethyl-5-isoxazolyl)-benzenesulfonamide

Synonyms:  NSC 13120|NSC 33807|NSC 38588|NSC 683536|Sulfafurazole

Molecular weight: 267.3

CAS: 127-69-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antibiotics|Sulfonamides||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia

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