Sulfapyridine – 10 g

Brand:
Cayman
CAS:
144-83-2
Storage:
-20
UN-No:
Non-Hazardous - /

Sulfapyridine is a sulfonamide antibiotic with antibacterial and anti-inflammatory activities.{45549} It is also a metabolite of sulfasalazine (Item No. 15025) formed through bacterial conversion in the colon.{45550} It is active against strains of Y. enterocolitica and Salmonella (MICs = 3.1-25 and 25-100 μg/ml, respectively), as well as S. aureus (MBC = 0.8 μM).{45551,45552} It is an inhibitor of recombinant P. carinii dihydropteroate synthetase (DHPS; IC50 = 0.18 μM).{38582} Sulfapyridine scavenges peroxyl radicals in an oxygen radical absorbance capacity (ORAC) assay.{45550} It inhibits histamine release induced by compound 48/80 (Item No. 22173) from isolated rat peritoneal mast cells in a dose-dependent manner.{45553} Sulfapyridine (1 μg/kg) also inhibits compound 48/80-induced systemic allergic reaction in rats. Formulations containing sulfapyridine have previously been used in the treatment of dermatological conditions and ulcerative colitis.  

 

Available on backorder

SKU: 28619 - 10 g Category:

Description

A sulfonamide antibiotic; active against strains of Y. enterocolitica and Salmonella (MICs = 3.1-25 and 25-100 μg/ml, respectively), as well as S. aureus (MBC = 0.8 μM); an inhibitor of recombinant P. carinii DHPS (IC50 = 0.18 μM); scavenges peroxyl radicals in an ORAC assay; inhibits compound 48/80-induced histamine release from rat peritoneal mast cells in a dose-dependent manner; inhibits compound 48/80-induced systemic allergic reaction in rats at 1 μg/kg


Formal name: 4-amino-N-2-pyridinyl-benzenesulfonamide

Synonyms:  NSC 41791|NSC 4753|Sulphapyridine

Molecular weight: 249.3

CAS: 144-83-2

Purity: ≥98%

Formulation: A crystalline solid