A sulfonamide antibiotic that inhibits the growth of Gram-negative bacteria and other microorganisms; inhibits recombinant P. carinii DHPS (IC50 = 17 nM); inhibits folate biosynthesis in P. carinii by 75% at 50 nM; inhibits any visible growth in culture tubes of 378 out of 530 E. coli isolates from necropsied animals and poultry at 0.25 mg/ml; decreases the number of viable amoxicillin-induced B. burgdorferi round body forms to 30% of control at 50 μM; decreases the number of P. carinii trophozoite and cyst lesions in lung tissue in a mouse model of pneumonia infection (ED50s = 0.06 and 0.08 mg/kg per day

Sulfamethoxypyridazine – 5 g

Brand:
Cayman
CAS:
80-35-3
Storage:
-20
UN-No:
Non-Hazardous - /

Sulfamethoxypyridazine is a sulfonamide antibiotic that inhibits the growth of Gram-negative bacteria and other microorganisms.{38582,43301,43302,43303} It inhibits recombinant P. carinii dihydropteroate synthase (DHPS; IC50 = 17 nM) and folate biosynthesis in P. carinii by 75% when used at a concentration of 50 nM.{38582} Sulfamethoxypyridazine (0.25 mg/ml) inhibits any visible growth in culture tubes of 378 out of 530 E. coli isolates from necropsied animals and poultry.{43301} It also decreases the number of viable amoxicillin-induced B. burgdorferi round body forms to 30% of control when used at a concentration of 50 μM.{43302} In vivo, sulfamethoxypyridazine decreases the number of P. carinii trophozoite and cyst lesions in lung tissue in a mouse model of pneumonia infection (ED50s = 0.06 and 0.08 mg/kg per day, respectively).{43303}  

 

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Description

A sulfonamide antibiotic that inhibits the growth of Gram-negative bacteria and other microorganisms; inhibits recombinant P. carinii DHPS (IC50 = 17 nM); inhibits folate biosynthesis in P. carinii by 75% at 50 nM; inhibits any visible growth in culture tubes of 378 out of 530 E. coli isolates from necropsied animals and poultry at 0.25 mg/ml; decreases the number of viable amoxicillin-induced B. burgdorferi round body forms to 30% of control at 50 μM; decreases the number of P. carinii trophozoite and cyst lesions in lung tissue in a mouse model of pneumonia infection (ED50s = 0.06 and 0.08 mg/kg per day, respectively)

Formal name: 4-amino-N-(6-methoxy-3-pyridazinyl)-benzenesulfonamide

Synonyms: 

Molecular weight: 280.3

CAS: 80-35-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Sulfonamides||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia||Research Area|Infectious Disease|Fungal Diseases|Pneumonia

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