A sulfonamide antibiotic; inhibits bacterial carbonic anhydrase by ~20% at a concentration of 500 μM; reduces severity of peribronchitis and inhibits cilia-associated respiratory Bacillus colonization in mice; prevents death of Toxoplasma-infected mice

Sulfamerazine (sodium salt) – 50 g

Brand:
Cayman
CAS:
127-58-2
Storage:
-20
UN-No:
Non-Hazardous - /

Sulfamerazine is a sulfonamide antibiotic.{38374} It inhibits bacterial carbonic anhydrase by ~20% at a concentration of 500 μM.{38376} In vivo, sulfamerazine (500 mg/L) reduces severity of peribronchitis and inhibits cilia-associated respiratory Bacillus colonization in mice.{38377} It also prevents death of Toxoplasma-infected mice.{38374} Sulfonamide class antibiotics, of which sulfamerazine is a member, are bacteriostatic and inhibit bacterial synthesis of dihydrofolic acid by competing with 4-aminobenzoic acid (Item No. 18659) for binding to dihydropteroate synthase.{38375} Formulations containing sulfamerazine have been used for the treatment of pneumonia and typhoid fever.{38378,38379}  

 

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SKU: 23380 - 50 g Category:

Description

A sulfonamide antibiotic; inhibits bacterial carbonic anhydrase by ~20% at a concentration of 500 μM; reduces severity of peribronchitis and inhibits cilia-associated respiratory Bacillus colonization in mice; prevents death of Toxoplasma-infected mice,

Formal name: 4-amino-N-(4-methyl-2-pyrimidinyl)-benzenesulfonamide, monosodium salt

Synonyms: 

Molecular weight: 286.3

CAS: 127-58-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Sulfonamides||Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Small Molecule Inhibitors|Carbonic Anhydrase||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia||Research Area|Infectious Disease|Bacterial Diseases|Typhoid||Research Area|Infectious Disease|Parasitic Diseases

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