A probucol derivative with diverse biological activities; inhibits hydrogen peroxide-induced oxidation of the redox-sensitive dye H2DCF in HPAECs and U937 cells at 5 and 10 µM; reduces LPS-induced production of IL-6

Succinobucol – 100 mg

Brand:
Cayman
CAS:
216167-82-7
Storage:
-20
UN-No:
Non-Hazardous - /

Succinobucol is a metabolically stable derivative of probucol (Item No. 15043) with diverse biological activities.{52866,52868,52867} It inhibits hydrogen peroxide-induced oxidation of the redox-sensitive dye H2DCF in human pulmonary artery endothelial cells (HPAECs) and U937 cells when used at concentrations of 5 and 10 µM.{52866} Succinobucol (0.3-10 µM) reduces LPS-induced production of IL-6, IL-1β, and TNF-α in peripheral blood mononuclear cells (PBMCs). It suppresses TNF-α-induced vascular cell adhesion molecule 1 (VCAM-1) promoter reporter gene expression in human aortic endothelial cells.{52868} Succinobucol (50 and 100 mg/kg) lowers plasma LDL levels and increases HDL levels in hypercholesterolemic cynomolgus monkeys.{52867} It also inhibits the formation of aortic atherosclerotic plaques in ApoE-/- or Ldlr-/- mice.  

 

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SKU: 30886 - 100 mg Category:

Description

A probucol derivative with diverse biological activities; inhibits hydrogen peroxide-induced oxidation of the redox-sensitive dye H2DCF in HPAECs and U937 cells at 5 and 10 µM; reduces LPS-induced production of IL-6, IL-1β, and TNF-α in PBMCs from 0.3-10 µM; lowers plasma LDL levels and increases HDL levels in hypercholesterolemic cynomolgus monkeys at 50 and 100 mg/kg; inhibits the formation of aortic atherosclerotic plaques in ApoE-/- or Ldlr-/- mice

Formal name: 1-[4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenyl] ester, butanedioic acid

Synonyms:  AGI-1067|Probucol Monosuccinate

Molecular weight: 616.9

CAS: 216167-82-7

Purity: ≥95%

Formulation: A crystalline solid

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