A potent inhibitor of PDGFRβ (IC50 = 10 nM); inhibits VEGFR2 (IC50 = 140 nM); selectively inhibits PDGF- over VEFG-

SU 16f – 1 mg

Brand:
Cayman
CAS:
251356-45-3
Storage:
-20
UN-No:
Non-Hazardous - /

SU 16f is a potent inhibitor of platelet-derived growth factor receptor β (PDGFRβ) with an IC50 value of 10 nM.{21720} It also inhibits VEGF receptor 2 (VEGFR2; IC50 = 140 nM). SU 16f selectively inhibits PDGF- over VEFG-, FGF-, and EGF-induced cell proliferation (IC50s = 0.11, 10, 10, and 21.9 μM, respectively). It also accelerates downregulation of fibroblast genes and increases the yield of beating clusters in human foreskin fibroblasts (HFFs) treated with 15 compounds to induce a cardiac myocyte-like phenotype.{31142}  

 

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Description

A potent inhibitor of PDGFRβ (IC50 = 10 nM); inhibits VEGFR2 (IC50 = 140 nM); selectively inhibits PDGF- over VEFG-, FGF-, and EGF-induced cell proliferation (IC50s = 0.11, 10, 10, and 21.9 μM, respectively); accelerates downregulation of fibroblast genes and increases the yield of beating clusters in HFFs treated with 15 compounds to induce a cardiac myocyte-like phenotype

Formal name: 5-[(1,2-dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid

Synonyms:  PDGFR Tyrosine Kinase Inhibitor VII

Molecular weight: 386.4

CAS: 251356-45-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cardiovascular System|Heart||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors

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