A glucosamine-nitrosourea which is commonly used to induce experimental diabetes in animals; specifically targets beta cells

Streptozotocin – 1 g

Brand:
Cayman
CAS:
18883-66-4
Storage:
-20
UN-No:
Non-Hazardous - /

Streptozotocin (STZ) is a glucosamine-nitrosourea which is commonly used to induce experimental diabetes in animals.{21671,21669} It specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA.{21670,21667} DNA damage induces activation of poly ADP-ribosylation, depletion of cellular NAD+ and ATP, and formation of superoxide radicals, leading to the destruction of beta cells.{21671} The effectiveness of STZ depends on the level of GLUT2 expression, which in turn may be influenced by age, sex, strain, or species.{21669,21668}  

 

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Description

A glucosamine-nitrosourea which is commonly used to induce experimental diabetes in animals; specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA, leading to the destruction of beta cells

Formal name: 2-deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucose

Synonyms:  Estreptozocin|NSC 37917|NSC 85998|Streptozocin|STZ|U 9889

Molecular weight: 265.2

CAS: 18883-66-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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