A phenylpyridylquinoline with diverse biological activities; induces DNA cleavage by calf thymus topoisomerase II; induces phage production in S. typhimurium from 1-10 μg/ml; inhibits DNA synthesis in and reduces survival of S. typhimurium bacteria at 10 μg/ml; bactericidal against E. coli in an iron-dependent manner; cytotoxic to human HT-29 colon carcinoma cells at 40 nM; inhibits mitosis and induces chromatin breaks in human leukocytes from 0.001-0.1 μg/ml; increases the mean survival time in rats infected with Rauscher virus at 0.05 mg/kg

Streptonigrin – 1 mg

Brand:
Cayman
CAS:
3930-19-6
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Streptonigrin is a phenylpyridylquinoline originally isolated from S. flocculus with diverse biological activities.{46268,46267,46269,46265,46266,46270} Streptonigrin (2.5-12.5 μM) induces DNA cleavage by calf thymus topoisomerase II in a concentration-dependent manner.{46268} It induces phage production in S. typhimurium when used at concentrations ranging from 1 to 10 μg/ml.{46267} Streptonigrin (10 μg/ml) inhibits DNA synthesis in and reduces survival of S. typhimurium bacteria. Streptonigrin is bactericidal against E. coli in an iron-dependent manner, an effect that is blocked by the iron chelators deferoxamine (Item No. 14595) and orthophenanthroline.{46269} Streptonigrin (40 nM) is cytotoxic to human HT-29 colon carcinoma cells but not to BE colon carcinoma cells in which NAD(P)H:quinone oxidoreductase is not expressed.{46265} Streptonigrin (0.001-0.1 μg/ml) inhibits mitosis and induces chromatin breaks in human leukocytes in a concentration-dependent manner.{46266} In vivo, streptonigrin (0.05 mg/kg, i.p.) increases the mean survival time in rats infected with Rauscher virus.{46270}  

 

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Description

A phenylpyridylquinoline with diverse biological activities; induces DNA cleavage by calf thymus topoisomerase II; induces phage production in S. typhimurium from 1-10 μg/ml; inhibits DNA synthesis in and reduces survival of S. typhimurium bacteria at 10 μg/ml; bactericidal against E. coli in an iron-dependent manner; cytotoxic to human HT-29 colon carcinoma cells at 40 nM; inhibits mitosis and induces chromatin breaks in human leukocytes from 0.001-0.1 μg/ml; increases the mean survival time in rats infected with Rauscher virus at 0.05 mg/kg

Formal name: (4R)-5-amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolinyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methyl-2-pyridinecarboxylic acid

Synonyms:  NSC 45383|NSC 56748|NSC 83950

Molecular weight: 506.5

CAS: 3930-19-6

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer|Cell Death||Research Area|Cancer|DNA Damage and Repair|Topoisomerase||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Bacterial Diseases|Food-borne Illnesses

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