An aminoglycoside antibiotic; inhibits growth of Gram-negative (MICs = 1.0 and 16 μg/mL for K. pneumoniae and S. marcescens

Streptomycin (sulfate) – 250 g

Brand:
Cayman
CAS:
3810-74-0
Storage:
-20
UN-No:
Non-Hazardous - /

Streptomycin is an aminoglycoside antibiotic that inhibits growth of both Gram-negative (MICs = 1 and 16 μg/mL for K. pneumoniae and S. marcescens, respectively) and Gram-positive bacteria (MIC = 0.25 μg/mL for S. pneumoniae).{40530} It inhibits growth of M. tuberculosis H37Rv (MIC = 5 μg/mL) and of susceptible strains from clinical isolates (MICs = ≤0.125-1 μg/mL).{40531,40532} Streptomycin (150 mg/kg), in combination with isoniazid (Item No. 20378), rifapentine (Item No. 20307), and moxifloxacin (Item No. 14830), administered once per week over 6 months to M. tuberculosis-inoculated mice results in clearance of the pathogen from the lungs of the majority of treated mice.{37311} However, after 3 months without treatment, 58% of treated mice produce a positive lung culture. Streptomycin acts by inhibiting protein synthesis in prokaryotes by binding to the 30S ribosomal subunit.{40528,37308,37310,40529} It has been used, in combination with penicillin G (Item No. 21615), in antibiotic cocktails to prevent bacterial growth in cell culture.{37309} Formulations containing streptomycin in combination with other antibiotics have been used to treat tuberculosis.  

 

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Description

An aminoglycoside antibiotic; inhibits growth of Gram-negative (MICs = 1.0 and 16 μg/mL for K. pneumoniae and S. marcescens, respectively) and Gram-positive bacteria (MIC = 0.25 μg/mL for S. pneumoniae); inhibits growth of M. tuberculosis H37Rv (MIC = 5 μg/mL) and of susceptible strains from clinical isolates (MICs = ≤0.125-1 μg/mL); once weekly administration at a dose of 150 mg/kg in combination with isoniazid, rifapentine, and moxifloxacin over 6 months to M. tuberculosis-inoculated mice results in clearance of the pathogen from the lungs in the majority of treated mice; however, after 3 months without treatment, 58% of treated mice produce a positive lung culture; used in antibiotic cocktails to prevent bacterial growth in cell culture

Formal name: O-2-deoxy-2-(methylamino)-α-L-glucopyranosyl-(1→2)-O-5-deoxy-3-C-formyl-α-L-lyxofuranosyl-(1→4)-N1,N3-bis(aminoiminomethyl)-D-streptamine

Synonyms: 

Molecular weight: 728.7

CAS: 3810-74-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Aminoglycosides||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis

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