Description
An aminoglycoside antibiotic; inhibits growth of Gram-negative (MICs = 1.0 and 16 μg/mL for K. pneumoniae and S. marcescens, respectively) and Gram-positive bacteria (MIC = 0.25 μg/mL for S. pneumoniae); inhibits growth of M. tuberculosis H37Rv (MIC = 5 μg/mL) and of susceptible strains from clinical isolates (MICs = ≤0.125-1 μg/mL); once weekly administration at a dose of 150 mg/kg in combination with isoniazid, rifapentine, and moxifloxacin over 6 months to M. tuberculosis-inoculated mice results in clearance of the pathogen from the lungs in the majority of treated mice; however, after 3 months without treatment, 58% of treated mice produce a positive lung culture; used in antibiotic cocktails to prevent bacterial growth in cell culture
Formal name: O-2-deoxy-2-(methylamino)-α-L-glucopyranosyl-(1→2)-O-5-deoxy-3-C-formyl-α-L-lyxofuranosyl-(1→4)-N1,N3-bis(aminoiminomethyl)-D-streptamine
Synonyms:
Molecular weight: 728.7
CAS: 3810-74-0
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Antibiotics|Aminoglycosides||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis
