Description
A bacterial metabolite with diverse biological activities; inhibits TNF-α-induced NF-κB transcriptional activity and decreases proliferation of HUVECs at 5-20 µM; decreases viability of, as well as induces apoptosis and increases the production of ROS in Hep3B cells at 12 µg/ml; does not induce cytotoxicity in RBL-2H3 mast cells at concentrations up to 100 µM; prevents degranulation in antigen-stimulated mast cells, and inhibits Syk, LYN, and Fyn kinases, and reduces DNP-HSA-induced TNF-α and IL-4 secretion in RBL-2H3 mast cells; decreases swelling and reduces scratching behavior in a mouse model of DNFB-induced allergic dermatitis
Formal name: 3-(4-chloro-5-oxazolyl)-1H-indole
Synonyms: SF 2583A
Molecular weight: 218.6
CAS: 120191-51-7
Purity: ≥98%
Formulation: A solid
Product Type|Biochemicals|Kinase Inhibitors|Other Non-Receptor Tyrosine Kinases||Product Type|Biochemicals|Kinase Inhibitors|SRC Family||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Ox Stress Reagents|Free Radical Generators||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cardiovascular System|Vasculature|Angiogenesis||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Innate Immunity
