A bacterial metabolite with diverse biological activities; inhibits protein synthesis in a cell-free assay at 50 μg/ml; inhibits the growth of S. cerevisiae and C. miyabeanus in a disc diffusion assay at 20 and 100 μg/disc; reduces tumor growth in H.S. No. 1 human sarcoma and H.Ep. No. 3 human epidermoid carcinoma rat xenograft models at 12.5 and 25 mg/kg per day

Streptimidone – 500 µg

Brand:
Cayman
CAS:
738-72-7
Storage:
-20
UN-No:
Non-Hazardous - /

Streptimidone is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities.{52313,52314,52315} It inhibits protein synthesis in a cell-free assay when used at a concentration of 50 μg/ml.{52314} Streptimidone (20 and 100 μg/disc) inhibits the growth of S. cerevisiae and the plant pathogenic fungus C. miyabeanus in a disc diffusion assay.{52313} It reduces tumor growth in H.S. No. 1 human sarcoma and H.Ep. No. 3 human epidermoid carcinoma rat xenograft models when administered at doses of 12.5 and 25 mg/kg per day.{52315}  

 

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Description

A bacterial metabolite with diverse biological activities; inhibits protein synthesis in a cell-free assay at 50 μg/ml; inhibits the growth of S. cerevisiae and C. miyabeanus in a disc diffusion assay at 20 and 100 μg/disc; reduces tumor growth in H.S. No. 1 human sarcoma and H.Ep. No. 3 human epidermoid carcinoma rat xenograft models at 12.5 and 25 mg/kg per day

Formal name: 4-[(2R,5S,6E)-2-hydroxy-5,7-dimethyl-4-oxo-6,8-nonadien-1-yl]-2,6-piperidinedione

Synonyms:  Ao58A|NSC 66645

Molecular weight: 293.4

CAS: 738-72-7

Purity: ≥95%

Formulation: A residue

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