An inhibitor of STK16 (IC50 = 295 nM); selective for STK16 over mTOR

STK16-IN-1 – 5 mg

Brand:
Cayman
CAS:
1223001-53-3
Storage:
-20
UN-No:
Non-Hazardous - /

STK16-IN-1 is an inhibitor of the serine/threonine kinase STK16 (IC50 = 295 nM).{46178} It is selective for STK16 over mTOR, PI3Kδ, and PI3Kγ in an enzyme assay (IC50s = 5,560, 856, and 867 nM, respectively) and over 440 additional kinases in a KinomeScan profiling assay. It decreases the growth of MCF-7 cells (GI50 = ~10 µM) and increases the number of binucleated cells. STK16-IN-1 (2.5-5 µM) potentiates the antiproliferative effects of colchicine (Item No. 9000760), paclitaxel (Item No. 10461), doxorubicin (Item No. 15007), and cisplatin (Item No. 13119) in MCF-7 cells.  

 

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SKU: 27370 - 5 mg Category:

Description

An inhibitor of STK16 (IC50 = 295 nM); selective for STK16 over mTOR, PI3Kδ, and PI3Kγ (IC50s = 5,560, 856, and 867 nM, respectively, in an enzyme assay) and over 440 additional kinases in a KinomeScan profiling assay; decreases the growth of MCF-7 cells (GI50 = ~10 µM); potentiates the antiproliferative effects of colchicine, paclitaxel, doxorubicin, and cisplatin in MCF-7 cells at 2.5-5 µM

Formal name: 1-(4-fluoro-3-methylphenyl)-1,7-dihydro-2H-pyrrolo[2,3-h]-1,6-naphthyridin-2-one

Synonyms: 

Molecular weight: 293.3

CAS: 1223001-53-3

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Research Area|Cancer|Cell Signaling

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