An inhibitor of Glut1 (IC50 = ~1 µM) that blocks glucose uptake and induces necrosis in cancer cells that lack VHL; inhibits NAMPT

STF-31 – 5 mg

Brand:
Cayman
CAS:
724741-75-7
Storage:
-20
UN-No:
Non-Hazardous - /

Glucose transporter 1 (Glut1) is an inducible carrier of pentoses and hexoses, including glucose. STF-31 is an inhibitor of Glut1 (IC50 = ~1 µM) that blocks glucose uptake.{20157} It induces necrosis in cancer cells that lack the von Hippel-Lindau tumor suppressor gene, which overexpress Glut1.{20157} Although STF-31 binds Glut1, suggesting a direct effect, STF-31 also inhibits nicotinamide phosphoribosyltransferase, an enzyme that induces Glut1 expression.{20157,28328,28326} STF-31 is also toxic to human pluripotent stem cells (hPSCs) and can be used to selectively eliminate hPSCs from mixed cultures.{28327}  

 

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SKU: 11173 - 5 mg Category:

Description

An inhibitor of Glut1 (IC50 = ~1 µM) that blocks glucose uptake and induces necrosis in cancer cells that lack VHL; inhibits NAMPT, an enzyme that induces Glut1 expression; toxic to hPSCs and can be used to selectively eliminate hPSCs from mixed cultures

Formal name: 4-[[[[4-(1,1-dimethylethyl)phenyl]sulfonyl]amino]methyl]-N-3-pyridinyl-benzamide

Synonyms: 

Molecular weight: 423.5

CAS: 724741-75-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Cancer|Cell Death|Necrosis||Research Area|Cell Biology|Stem Cell Research||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism

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