A cyclopropene fatty acid; an inhibitor of Δ9-desaturase; decreases 9(Z)-myristoleic acid and increases oleic acid and 9(Z)

Sterculic Acid – 25 mg

Brand:
Cayman
CAS:
738-87-4
Storage:
-20
UN-No:
Non-Hazardous - /

Sterculic acid is a cyclopropene fatty acid that has been found in S. foetida.{46110} It is an inhibitor of Δ9-desaturase that decreases 9(Z)-myristoleic acid (Item No. 9002461) and increases oleic acid (Item No. 90260) and 9(Z),11(E)-conjugated linoleic acid (Item No. 90140) levels in the milk of lactating ewes when administered at a dose of 0.5 g per day.{48112} It also inhibits endoplasmic reticulum stress induced by 7-keto cholesterol (Item No. 16339) in ARPE-19 cells when used at a concentration of 1 µM and prevents the formation of choroidal neovascularization when applied to eyes at concentrations of 0.1 to 10 mM in a rat model of macular degeneration induced by laser injury.{46110} Sterculic acid binds to a variety of kinases, including calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2), mammalian sterile20-related kinase 3 (MST3), and p90 ribosomal S5 kinase 4 (RSK4).{46111} [Matreya, LLC. Catalog No. 1235]  

 

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SKU: 26735 - 25 mg Category:

Description

A cyclopropene fatty acid; an inhibitor of Δ9-desaturase; decreases 9(Z)-myristoleic acid and increases oleic acid and 9(Z),11(E)-conjugated linoleic acid in the milk of lactating ewes at 0.5 g per day; inhibits 7-keto cholesterol-induced endoplasmic reticulum stress in ARPE-19 cells at 1 µM; prevents the formation of choroidal neovascularization via topical administration of 0.1-10 mM solutions in a rat model of macular degeneration induced by laser injury; binds to a variety of kinases

Formal name: 2-octyl-1-cyclopropene-1-octanoic acid

Synonyms: 

Molecular weight: 294.5

CAS: 738-87-4

Purity: ≥98%

Formulation: A liquid

Product Type|Biochemicals|Lipids|Fatty Acids||Product Type|Biochemicals|Small Molecule Inhibitors|Fatty Acid Metabolism||Research Area|Lipid Biochemistry|Fatty Acids|Synthesis||Research Area|Neuroscience|Ophthalmology

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