An anthracycline bacterial metabolite; binds to DNA

Steffimycin B – 1 mg

Brand:
Cayman
CAS:
54526-94-2
Storage:
-20
UN-No:
Non-Hazardous - /

Steffimycin B is an anthracycline bacterial metabolite originally isolated from Streptomyces.{47377} It binds to DNA, preferentially intercalating at sites containing cytosine and guanine.{47381} Steffimycin B is cytotoxic to MCF-7, KB, NCI-H187, and Vero cells (IC50s = 3.5, 6.75, 3.28, and 10.5 μM, respectively).{47382} It is active against M. tuberculosis (MIC = 5.2 nM), B. cereus (MIC = 1.56 μg/ml), and P. falciparum (IC50 = 2.19 μM).  

 

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SKU: 28087 - 1 mg Category:

Description

An anthracycline bacterial metabolite; binds to DNA, preferentially intercalating at sites containing cytosine and guanine; is cytotoxic to MCF-7, KB, NCI-H187, and Vero cells (IC50s = 3.5, 6.75, 3.28, and 10.5 μM, respectively); is active against M. tuberculosis (MIC = 5.2 nM), B. cereus (MIC = 1.56 μg/ml), and P. falciparum (IC50 = 2.19 μM)

Formal name: (2S,3S,4R)-4-[(6-deoxy-2,4-di-O-methyl-α-L-mannopyranosyl)oxy]-3,4-dihydro-2,5,7-trihydroxy-3,9-dimethoxy-2-methyl-1,6,11(2H)-naphthacenetrione

Synonyms:  NSC 204855|U 40615

Molecular weight: 588.6

CAS: 54526-94-2

Purity: ≥99%

Formulation: A lyophilisate

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