An inhibitor of HIV reverse transcriptase; inhibits HIV-1 replication in PBMCs (EC50 = 8.8 nM); reduces the synthesis of HIV-specific antigen in MT-4 cells at 0.1-10 µg/ml; reduces HIV-induced plaque formation in MT-4 cells at 0.05 µg/ml; reduces plasma- and cell-associated viral load in HIV-2-infected macaques; induces sustained hind paw mechanical allodynia in a rat model of ATN at a cumulative dose of 375 mg/kg

Stavudine – 1 g

Brand:
Cayman
CAS:
3056-17-5
Storage:
-20
UN-No:
Non-Hazardous - /

Stavudine is an inhibitor of HIV reverse transcriptase and a derivative of the nucleoside thymidine (Item No. 20519).{53215} It inhibits HIV-1 replication in human peripheral blood mononuclear cells (PBMCs; EC50 = 8.8 nM). Stavudine reduces the synthesis of HIV-specific antigen in MT-4 cells when used at concentrations ranging from 0.1 to 10 µg/ml and reduces HIV-induced plaque formation in MT-4 cells at 0.05 µg/ml.{29420} It reduces plasma- and cell-associated viral load in macaques infected with a highly pathogenic isolate of HIV-2.{53216} Stavudine induces sustained hind paw mechanical allodynia in a rat model of antiretroviral toxic neuropathy (ATN) when administered at a dose of 75 mg/kg twice weekly for five consecutive doses for a cumulative dose of 375 mg/kg.{53217} Formulations containing stavudine, in combination with other antiretrovirals, have been used in the treatment of HIV-1 infection.  

 

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Description

An inhibitor of HIV reverse transcriptase; inhibits HIV-1 replication in PBMCs (EC50 = 8.8 nM); reduces the synthesis of HIV-specific antigen in MT-4 cells at 0.1-10 µg/ml; reduces HIV-induced plaque formation in MT-4 cells at 0.05 µg/ml; reduces plasma- and cell-associated viral load in HIV-2-infected macaques; induces sustained hind paw mechanical allodynia in a rat model of ATN at a cumulative dose of 375 mg/kg

Formal name: 2′,3′-didehydro-3′-deoxy-thymidine

Synonyms:  BMY 27857|d4T|NSC 163661

Molecular weight: 224.2

CAS: 3056-17-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Nucleoside Reverse Transcriptase Inhibitors (NRTIs)||Product Type|Biochemicals|Small Molecule Inhibitors|Reverse Transcriptases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS||Research Area|Neuroscience|Pain Research

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