Primes embryonic stem cells for differentiation (EC50 = 0.3 μM) in lineage specification stimulus cues by inhibiting the nuclear localization of NME2 and down-regulating c-Myc expression

Stauprimide – 500 µg

Brand:
Cayman
CAS:
154589-96-5
Storage:
-20
UN-No:
Non-Hazardous - /

Stauprimide is a small molecule that increases the efficiency of mouse and human embryonic stem cell differentiation in conjunction with lineage specification cues (EC50 = 0.3 μM).{24988} It specifically inhibits the nuclear localization of NME2, which results in the suppression of c-Myc, a key regulator of pluripotency.{24988}  

 

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Description

Primes embryonic stem cells for differentiation (EC50 = 0.3 μM) in lineage specification stimulus cues by inhibiting the nuclear localization of NME2 and down-regulating c-Myc expression

Formal name: N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1,3-dioxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl-benzamide

Synonyms:  N-Benzoyl-7-oxo Staurosporine

Molecular weight: 584.6

CAS: 154589-96-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cell Biology|Stem Cell Research|Differentiation

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