An aldose reductase inhibitor that blocks the conversion of glucose to sorbitol (Kis = 7.7 nM and 60 µM

Statil – 10 mg

Brand:
Cayman
CAS:
72702-95-5
Storage:
-20
UN-No:
Non-Hazardous - /

Statil is an aldose reductase inhibitor that blocks the conversion of glucose to sorbitol. It demonstrates selectivity for aldose reductase 2 over aldose reductase 1 with Ki values of 7.7 nM and 60 µM, respectively.{31161} Statil has been shown to prevent diabetes-induced alterations of the cardiovascular system in 14-day streptozotocin-diabetic rats.{31160} Aldose reductase inhibition by statil has also been used to impair the synthesis of prostaglandin F2α by human cultured preadipocytes.{31159}  

 

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Description

An aldose reductase inhibitor that blocks the conversion of glucose to sorbitol (Kis = 7.7 nM and 60 µM, for aldose reductase 2 and 1, respectively); prevents diabetes-induced alterations of the cardiovascular system in 14-day streptozotocin-diabetic rats; impairs the synthesis of PGF2α by human cultured preadipocytes.

Formal name: 3-[(4-bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid

Synonyms:  ICI 128436|MK-538|Ponalrestat

Molecular weight: 391.2

CAS: 72702-95-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cardiovascular System|Cardiovascular Diseases||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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