Potently inhibits STAT3 by preventing its dimerization and DNA binding at concentrations of 20-30 μM; blocks the growth and survival of cancer cells that express constitutively active Stat3 (e.g.

STA-21 – 500 µg

Brand:
Cayman
CAS:
28882-53-3
Storage:
-20
UN-No:
Non-Hazardous - /

STA-21 is a natural antibiotic that potently inhibits STAT3 by preventing its dimerization and DNA binding when used at concentrations of 20-30 μM.{24347} It blocks the growth and survival of cancer cells that express constitutively active STAT3 (e.g., DU145 cells, IC50 = 12.2 μM).{24347,24349,24348} STAT3 inhibitors, including STA-21, prevent the proliferation of human keratinocytes and have value in improving psoriasis.{24350}  

 

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Description

Potently inhibits STAT3 by preventing its dimerization and DNA binding at concentrations of 20-30 μM; blocks the growth and survival of cancer cells that express constitutively active Stat3 (e.g., DU145 cells, IC50 = 12.2 μM); prevents the proliferation of human keratinocytes and has value in improving psoriasis

Formal name: (3S)-3,4-dihydro-8-hydroxy-3-methyl-benz[a]anthracene-1,7,12(2H)-trione

Synonyms:  Ochromycinone

Molecular weight: 306.3

CAS: 28882-53-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Signaling|JAK/STAT Signaling||Research Area|Cancer|Transcription Factors|STATs

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