An adenylyl cyclase 1 inhibitor (IC50 = 2.3 µM); inhibits AC1 activation induced by A23187

ST034307 – 10 mg

Brand:
Cayman
CAS:
133406-29-8
Storage:
-20
UN-No:
Non-Hazardous - /

ST034307 is an inhibitor of adenylyl cyclase 1 (AC1), a membrane-bound AC, with an IC50 value of 2.3 µM for A23187-stimulated cAMP accumulation in HEK293 cells transfected with AC1.{38508} It also inhibits AC1 activation induced by forskolin (Item No. 11018) or isoproterenol (Item No. 15592) in vitro. It is selective for AC1 over other membrane-bound AC isoforms. ST034307 enhances the inhibition of AC1 by the µ-opioid receptor (MOR) agonist DAMGO (Item No. 21553) in HEK293 cells transfected with AC1 and MOR. In a mouse model of inflammatory pain, ST034307 reduces hypersensitivity to touch in mouse hind paw (ED50 = 0.28 µg), which is blocked by forskolin.  

 

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Description

An adenylyl cyclase 1 inhibitor (IC50 = 2.3 µM); inhibits AC1 activation induced by A23187, forskolin, or isoproterenol in vitro; selective for AC1 over other membrane-bound AC isoforms; enhances the inhibition of AC1 by the MOR agonist DAMGO in vitro; reduces hypersensitivity to touch in mouse hind paw (ED50 = 0.28 µg) in a mouse model of inflammatory pain

Formal name: 6-chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one

Synonyms: 

Molecular weight: 298

CAS: 133406-29-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cell Biology|Cell Signaling|cAMP Signaling||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Pain Research

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