Description
A potent inhibitor of neutrophil elastase (Ki = 0.0168 nM for the human enzyme); selective for human neutrophil elastase over rat, mouse, and rabbit elastases (Kis = 3, 1.8, 58 nM, respectively); inhibits human neutrophil elastase ex vivo in mouse BAL fluid (ED50 = 10.5 mg/kg, p.o.); reduces acute lung hemorrhage induced by human neutrophil elastase in mice (2.8 mg/kg, p.o.); reduces carrageenan- and human neutrophil elastase-induced paw edema in rats (ED30s = 2.2 and 2.7 mg/kg, respectively); reduces cardiac infarct size in a rabbit model of ischemia-reperfusion injury,
Formal name: 2-[[6-methoxy-4-(1-methylethyl)-1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]methoxy]-9-[2-(1-piperidinyl)ethoxy]-4H-pyrido[1,2-a]pyrimidin-4-one
Synonyms:
Molecular weight: 556.6
CAS: 344930-95-6
Purity: ≥95%
Formulation: A crystalline solid
Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Immunology & Inflammation|Innate Immunity